Are you suffering from painful Gynecomastia? This might relate to you: conditions that cause primary or secondary hypogonadism can lead to gynecomastia. Primary hypogonadism could be related to a congenital abnormality such as Klinefelter syndrome, an enzymatic defect in testosterone biosynthesis, infection, infiltrative disorders, testicular trauma, aging, or use of 5ar inhibitors such as Finasteride. The associated reduction in testosterone production leads to a decrease in the serum testosterone concentration and a compensatory rise in leuteinizing hormone release. While the net effect is an increase in estradiol relative to testosterone secretion, The excess LH results in enhanced Leydig cell stimulation with 17 inhibition,20lyase and 17hydroxylase activities and increased aromatization of testosterone to estradiol. So basically Estrogen goes up and DHT goes down and whammo… you have man boobs.
What to do to get rid of your man boobs:
Of course there is surgery but it is an expensive and intensive process. There is another alternative to try that may suit you better:
First you need to determine if you have hard painful lumps, fatty tissue or both. For hard glandular lumps the first line of treatment is topical DHT such as Andractim found here. This will consume the Gynecomastia tissues. Along with DHT you should try to lower your Estrogen profile. Eat a lot of broccoli. Take supplements known to lower Estrogen (DIM, Resveratrol, Erase etc.).
For fatty tissue you will need to change your lifestyle. You must lose fat all through your body not just on the chest that doesn’t work! Cut what you eat down by a third. Cut out sugar and refined flour products. Workout your whole body both cardio and weights. This type of lifestyle change will help reduce your chest fat.
Gynecomastia is defined clinically by the presence of a rubbery or firm mass extending concentrically from the nipples. The condition famous as pseudogynecomastia, or lipomastia, is characterized fat deposits but no glandular proliferation. Gynecomastia results from an altered estrogen androgen balance, in favor of estrogen, or from increased breast sensitivity to a normal circulating estrogen level. The imbalance is between the stimulatory effect of estrogen and the inhibitory effect of androgens, in this case DHT.
Actually, older men are more likely to get medications related to gynecomastia than are younger men. Finasteride is a big one and that is used for prostate enlargement and more recently hairloss. This drug increases estrogen while decreasing DHT. Estrogen production in males results mainly from the peripheral conversion of androgens to estradiol and estrone, which occurs thru action of the enzyme the action aromatase. The testes secrete usually ‘6 10’ mg of estradiol and five estrone mg per week. The remainder of estrogen in males is derived from the extraglandular aromatization of testosterone and androstenedione to estradiol and estrone, since this solely makes up a little fraction of estrogens in circulation. It is and accordingly, any cause of estrogen excess from overproduction to peripheral aromatization of androgens can initiate the cascade to breast development.
Gynecomastia is seen in newborn infants, pubescent adolescents, and elderly gentlemen. Aside from the associated risk of breast cancer, gynecomastia does not cause any ‘long-term’ complications, that is physically. Mentally is a whole different ballgame. Young adults and men who get Gynecomastia are often devastated by it. There lives are altered in a very negative way. Shame and embarrassment are common. Socially there is often a decline.